It is the first work to show that sonothermogenetics can control behavior by stimulating a specific target deep in the brain — ScienceDaily


Neurological disorders such as Parkinson’s disease and epilepsy have had some treatment success with deep brain stimulation, but those require surgical device implantation. A multidisciplinary team at Washington University in St. Louis has developed a new brain stimulation technique using focused ultrasound that is able to turn specific types of neurons in the brain on and off and precisely control motor activity without surgical device implantation.

The team, led by Hong Chen, assistant professor of biomedical engineering in the McKelvey School of Engineering and of radiation oncology at the School of Medicine, is the first to provide direct evidence showing noninvasive, cell-type-specific activation of neurons in the brain of mammal by combining ultrasound-induced heating effect and genetics, which they have named sonothermogenetics. It is also the first work to show that the ultrasound- genetics combination can robustly control behavior by stimulating a specific target deep in the brain.

Results of the three years of research, which was funded in part by the National Institutes of Health’s BRAIN Initiative, were published online in Brain Stimulation May 11, 2021.

The senior research team included experts from both the McKelvey School of Engineering and the School of Medicine, including Jianmin Cui, professor of biomedical engineering; Joseph P. Culver, professor of radiology, of physics and of biomedical engineering; Mark J. Miller, associate professor of medicine in the Division of Infectious Diseases in the Department of Medicine; and Michael Bruchas, formerly of Washington University, now professor of anesthesiology and pharmacology at the University of Washington.

“Our work provided evidence that sonothermogenetics evokes behavioral responses in freely moving mice while targeting a deep brain site,” Chen said. “Sonothermogenetics has the potential to transform our approaches for neuroscience research and uncover new methods to understand and treat human brain disorders.”

Using a mouse model, Chen and the team delivered a viral construct containing TRPV1 ion channels to genetically-selected neurons. Then, they delivered small burst of heat via low-intensity focused ultrasound to the select neurons in the brain via a wearable device. The heat, only a few degrees warmer than body temperature, activated the TRPV1 ion channel, which acted as a switch to turn the neurons on or off.

“We can move the ultrasound device worn on the head of free-moving mice around to target different locations in the whole brain,” said Yaoheng Yang, first author of the paper and a graduate student in biomedical engineering. “Because it is noninvasive, this technique has the potential to be scaled up to large animals and potentially humans in the future.”

The work builds on research conducted in Cui’s lab that was published in Scientific Reports in 2016. Cui and his team found for the first time that ultrasound alone can influence ion channel activity and could lead to new and noninvasive ways to control the activity of specific cells. In their work, they found that focused ultrasound modulated the currents flowing through the ion channels on average by up to 23%, depending on channel and stimulus intensity. Following this work, researchers found close to 10 ion channels with this capability, but all of them are mechanosensitive, not thermosensitive.

The work also builds on the concept of optogenetics, the combination of the targeted expression of light-sensitive ion channels and the precise delivery of light to stimulate neurons deep in the brain. While optogenetics has increased discovery of new neural circuits, it is limited in penetration depth due to light scattering and requires surgical implantation of optical fibers.

Sonothermogenetics has the promise to target any location in the mouse brain with millimeter-scale resolution without causing any damage to the brain, Chen said. She and the team continue to optimize the technique and further validate their findings.

Story Source:

Materials provided by Washington University in St. Louis. Original written by Beth Miller. Note: Content may be edited for style and length.

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Deep water aqua


Date & time

Mon 17 May 2021
10:30am to 11:30am

Add to Calendar
2021-05-17 10:30
2021-05-17 11:30
Australia/Brisbane
Deep water aqua
Bookings essential. Deep Water Aqua is an aquatic workout that uses all major muscle groups. Suitable for all fitness levels. Participants wear a buoyancy belt so there’s no need to worry about being in deep water; however, participants do require basic swimming skills.

This is a GOLD event suitable for seniors.
Jindalee Pool, 11 Yallambee Road, Jindalee

Age

Seniors

Cost

Pool entry

Deep water aqua

Bookings essential. Deep Water Aqua is an aquatic workout that uses all major muscle groups. Suitable for all fitness levels. Participants wear a buoyancy belt so there’s no need to worry about being in deep water; however, participants do require basic swimming skills.

Bookings

Bookings essential. To book phone Jindalee Pool on 3376 1002.

Requirements

Buoyancy belt is compulsory. Can be purchased from the pool for $45 or purchased at most sports stores.

Meeting point

At reception.

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Neighbours dig deep to buy Geelong West renovation project


Seven bidders contested 22 Potter Street, Geelong West at Saturday’s auction.


Geelong West buyers who know the value of their own backyard have paid a big premium to get their hands on an untouched renovation project next door.

Seven bidders contested the original three-bedroom bungalow at 22 Potter Street, pushing the sale price $200,000 above expectation.

The immediate neighbours secured the 483sq m north-facing property for $831,000 at Saturday’s auction.

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Stockdale & Leggo, Belmont agent Rod van der Chys calls the auction.


A big crowd braved the wintry weather to attend on Saturday.


Dual street frontages onto Potter and Lupton streets opens to the door to a rear extension or possible townhouse development at the property.

Stockdale & Leggo, Belmont agent Rod van der Chys said the flexibility to add value underpinned the depth of competition from renovators, developers and builders.

Bidding opened at $640,000 — more than what the vendors were hoping for — but the eventual buyers only entered the race at $823,000.

The kitchen is due for an update.


The wide entrance hall is surprisingly spacious.


Mr van der Chys said the high opening bid immediately knocked several interested parties out of the competition.

“I thought (the buyers’) strategy of coming in at the very last minute was very clever,” he said.

“We were just about to knock it down and the others had said they were out so it’s quite disheartening for the other bidder.

“But you have got to have the money to take it off them — deep pockets is the only strategy that works in a market like this.”

The dual street access appealed to potential buyers.


He said the neighbours did not revealed their plans for the almost 100-year-old house but clearly couldn’t pass up an opportunity in a part of Geelong West they know and love.

The house comes with a loungeroom, kitchen/meals area, a central bathroom and rear sunroom, plus a garage with rear access.

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A&H deep water running



Tuesday, May 11, 2021, 10:15 – 11am

A&H deep water running

Deep water running is the perfect choice for those with injuries or limitations. These beginner classes introduce you to the joy of working out and improving mobility without any worries about strain or injury.

Venue: Palm Beach Aquatic Centre
Address: Thrower Drive, Palm Beach
Suburb: Palm Beach
Bookings required: No
Category: Aqua classes
Contact name: Palm Beach Aquatic Centre
Contact phone: 5534 4188
Cost: $5

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Deep Throat Drive-in


Deep Throat Drive-in

Deep Throat Drive-inDeep Throat Drive-in

DROMANA DRIVE-IN

DEEP THROAT DRIVE-IN

Sandi Sissel with Willoh Weiland and James Brennan

Buckle up for an intimate night of cinema at Dromana Drive-In.

On the way down the highway a voice comes over your car radio. Deep Throat’s taken over the station and they’re going to school scare and guide you beyond the cinematic male gaze. They have some avenging to do.   

Deep Throat Drive-In—devised by celebrated cinematographer Sandi Sissel with Willoh Weiland and James Brennan—is a rewilding of the drive-in space. It journeys through Sandi’s forty year career in journalism and film examines misogyny tropes and affirms non-binary and gender diverse bodies in cinema. 

Australian goth meets Hollywood kitsch in a night of classic cars monstrous performers speaker stacks and back-seat make outs. Order up buckets of popcorn and let Deep Throat lead you into what can best be described as a live and recut sex-positive night at the flicks.

Venue Dromana Drive-In

Dates Fri 4—Sat 5 June gates open 7PM

Duration 4 hours

Price $100 per car + booking fee

Warnings 18+ event. Adult and sexual themes coarse language violence drug use and nudity

Note Please arrive as close to 7PM as possible to allow time for parking and to enjoy the specially programmed audio warm up.


❊ When & Where ❊

Date/s: Friday 4th June 2021 – Saturday 5th June 2021

Times: 7pm

❊ Venue ❊

 Dromana 3 Drive-In  Events 1
Events
⊜ 113 Nepean Highway Dromana | Map

Dromana 3 Drive-In113 Nepean Highway, Dromana, , 3936

✆ Event: | Venue: 03 5931 0022

Book Online Here

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❊ Be Social ❊

❊ CoronaVirus Update ❊

As Victoria takes action to stop the spread of COVID-19, events may be cancelled, businesses and venues may close.

→ Disclaimer: Check with the operator before making plans.


❊ Web Links ❊

Deep Throat Drive-in

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Candles lit for murdered PCSO Julia James as Kent Police say they are ‘in deep shock’


The tribute paid by mourners and members of the public across the country came after Kent Police’s top officer said the force was “in deep shock” following her death.

Chief Constable Alan Pughsley said the force would do “all we can” to bring her killer to justice, but warned the community to be “very safe and very careful”.

No arrests have been made in connection with the killing of the Kent PCSO, as police consider “all possible” motives to the incident which happened near Dover in Kent.

The police chief’s words came as mourners left candles on their doorsteps at 7pm on Tuesday.

Meanwhile Prime Minister Boris Johnson paid tribute to Ms James as the vigil was held in her memory.

Writing on Twitter, Mr Johnson said: “Tonight we remember PCSO Julia James. My thoughts are with her friends and family.”

Speaking to ITV after visiting flowers left in her memory, Kent’s chief constable vowed to find Ms James’ killer.

He said: “You can imagine that the force are in deep shock with regard to what’s happened to Julia.

“We will do all we can to find out whoever did this to bring them to justice.”

Tuesday marks a week since the 53-year-old’s body was found in Akholt Wood, close to her home in the village of Snowdown.

The popular PCSO – described as “fiercely loyal” by her devastated family – died from serious head injuries while out walking her dog.

In a Facebook post, her daughter Bethan Coles said: “A number of people have asked about holding a vigil for Mum, and whilst I am so grateful for people wanting to remember her, I am very conscious that any gathering would need to be policed (if it was even allowed).

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Catalyzing Innovation In Deep Tech (VIDEO)



AsianScientist (Apr. 30, 2021) – Gone are the days when researchers are relegated to university hallways and facilities. Today, we see an increasing number venturing beyond the four walls of the laboratory and into the exciting, fast-paced world of entrepreneurship.

Case in point: Dr. Robert “Bob” Langer—academic cofounder of COVID-19 vaccine manufacturer Moderna—who is perhaps the most cited engineer in history. Aside from Moderna, Langer has founded over 40 other biotechnology companies, exemplifying the term scientist-entrepreneur. But it’s not just in biotech and big pharma that we are seeing this trend. In the deep tech arena especially, more and more scientists are taking a leap of faith and creating companies of their own.

From ultra-sensitive disease detection tools to high-speed wireless networks, deep tech innovations are pushing the frontiers of science and technology. Instead of making small tweaks, deep tech disrupts existing systems to solve society’s most pressing issues in society. Despite this, deep tech startups often struggle to attract investors, noted SGInnovate CEO Dr. Lim Jui.

“Deep tech investment is a high-risk, high-return endeavor,” he explained. “Traditional roadmaps for market expansion may not apply due to its long gestation period. And that’s on top of the technology risk and typically higher capital requirements.”

Accordingly, knocking down these barriers has become the mission of SGInnovate, which equips aspiring scientist-entrepreneurs with extensive resources to build and scale their deep tech startups in Singapore and worldwide. SGInnovate achieves this via three strategic pillars, namely talent training, venture building and investing as well as community support.

Through SGInnovate’s workshops and workplace immersion programs, rising talents hone their technical capabilities as they gear up to shape the future of deep tech. According to Lim, these apprenticeship opportunities match students, fresh graduates and early-career professionals with budding deep tech ventures, allowing them to partake in immersive experiences across different fields like cybersecurity and data analytics.

But building a capable team is only half the battle, as young companies also need financial backing to scale up. As an early-stage supporter, SGInnovate’s investments of over S$50 million have catalyzed the launch of everything from smart robots that pinpoint injury sites for surgery to artificial intelligence platforms for complex business decision-making.

While deep tech’s promise of high returns and big impact can entice funding, Lim is also acutely aware of the risks that investors must consider before pledging their support. By providing initial capital to high-potential startups, he and his team look to encourage other investors to do the same.

By showcasing up-and-coming entrepreneurial scientists and their inventions, SGInnovate’s community events are the perfect platform to stimulate interest from investors and corporate partners. Their Deep Tech Summit, for instance, brings together thought leaders and industry experts into one room, Zoom or otherwise, to exchange perspectives and spark new ideas in deep tech.

“A big part of our work is in educating and helping the private sector to understand the opportunities in deep tech,” explained Lim. “We hope to create a mindset shift to attract more investors and talents to take the plunge into deep tech with us.”

As the pandemic unfolded, the demand for science and technology roles skyrocketed across industries, noted Lim. With innovations being pushed quickly along the development pipeline, Singapore’s wealth of scientist-entrepreneurs rose to the occasion, devising research-backed solutions not just in healthcare, but even in e-commerce, education and transport.

“COVID-19 and the ensuing response from the scientific community have magnified the importance of deep science and technology in addressing challenges that confront humanity,” Lim said.

One noteworthy example is SGInnovate-backed biotech company Lucence—a pioneer in early cancer detection. When the pandemic struck, Lucence quickly shifted its focus to developing a new medium for the long-term preservation of viral genetic material in test samples at room temperature. Aside from allowing safer and more accessible testing, Lucence’s medium for nasopharyngeal swab samples led to a 36 percent higher SARS-CoV-2 detection rate compared to the standard.

Another Singapore-based startup, Accredify, worked with SGInnovate to launch the Digital Health Passport for the better management of medical records. Whether it is swab test results or vaccination history, patient data is stored in a digital wallet secured by blockchain and authenticated with a simple QR code scan. As border restrictions ease, this contactless and tamper-proof alternative to physical documents may become the ticket for a safe and smooth traveling experience in a post-COVID world.

With COVID-19 accelerating society’s digital transformation, a more integrated deep tech nexus on the horizon in Singapore. By standing at the interface between academia and industry, Lim believes that scientist-entrepreneurs are in the best position to turn research into social impact by embarking on their own deep tech journeys.

“Be brave and unafraid to take risks,” he concluded. “This means always keeping an open mind to try new things; always learning and upskilling; as well as being flexible and adaptable when challenges come your way.”

———

Copyright: Asian Scientist Magazine.
Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.


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A deep look at the slander industry, and the symbiotic relationship between the sites that host slander and the "reputation management" companies who remove it (New York Times)




New York Times:

A deep look at the slander industry, and the symbiotic relationship between the sites that host slander and the “reputation management” companies who remove it  —  I wanted to slander someone.  —  My colleague Kashmir Hill and I were trying to learn who is responsible for …



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#deep #slander #industry #symbiotic #relationship #sites #host #slander #quotreputation #managementquot #companies #remove #York #Times



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Ding attacks toddler on Fraser Island, inflicting deep puncture wounds


A toddler is in hospital with deep puncture wounds inflicted by a dingo which attacked the two-year-old boy who walked unsupervised from his family’s holiday home on Fraser Island.

The young boy sustained significant injuries to his legs, arms, neck, shoulder and head after being mauled by just one animal, with a paramedic saying he was lucky not to be attacked by a dingo pack.

Neighbours at Orchid Beach on the island’s northeastern coast raised the alarm after hearing a commotion around 7.30am on Saturday.

The two-year-old had wandered outside while his family was asleep and was approached by a dingo, on duty paramedic Lee told the Courier-Mail.

Lee said the dingo bit the boy on many parts of his body as well as the back of his head.

“The young lad had sustained bite marks and puncture wounds to his left leg, left arm, base of neck, shoulder and a laceration to the base of his head and the back as well,” Lee said.

“None of these wounds were life-threatening but some were quite deep puncture marks.

“This child was extremely lucky to not sustain worse injuries as it was believed to be a single dingo and not a pack.”

The toddler was saved after nearby residents heard the attack taking place.

“I believe it may have been neighbours in houses nearby, heard the commotion going on outside and they dealt with it,” the paramedic said.

The boy was airlifted to Bundaberg Hospital where he is in a stable condition.

Fraser Island, the largest sand island in the world, has a history of dingo attacks, with one incident in 2019 serving as an eerie reminder of the Azaria Chamberlain case

A pack of dingoes dragged a 14-month-old boy by the head from his family’s caravan after midnight.

It was only the boy’s cries waking his father, who wrestled his son away from the pack, that saved the boy.

The ninth attack on Fraser Island in 20 years, it was similar to the infamous 1980 case when nine-week-old Azaria Chamberlain was taken from her family tent near Uluru in the Northern Territory.

Lindy Chamberlain was convicted of murdering her child and spent three years of a life sentence in jail.

Then, by chance, the baby’s bloodied matinee jacket was found in a dingo’s lair at Uluru.

Ms Chamberlain was released, exonerated and financially compensated.

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COVID-19 detected in Brisbane’s Princess Alexandra Hospital ward 5D despite deep cleaning


The hospital has been locked down twice in recent months, after two workers in the 5D ward contracted the virus from a positive returned traveller.

Deep cleaning was conducted last week by contractors engaged by the Department of Housing and Public Works.

But further cleaning will resume today after testing found “COVID-19 related virus” in the ward.

It remains closed.

A spokesperson for Metro South Health said engineering consultants are conducting reviews, but maintenance reports indicate all isolation rooms were functioning to their design specification.

Infectious diseases expert at Griffith University Professor Nigel McMillan told ABC Radio Brisbane tests would have detected traces of the virus that were not alive or infectious.

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