Twitter’s Censorship Method – WSJ


What a depressing spectacle. On Wednesday the Senate Commerce Committee held a hearing on online speech, questioning the CEOs of Twitter, Facebook and Google. Twitter’s Jack Dorsey was the focus, two weeks after his company launched a crackdown against independent journalists to protect Joe Biden from public scrutiny. Twitter blocked all links to a New York Post story on Hunter Biden’s business dealings, and the Post’s account remains locked to this day.

The dazed-looking Mr. Dorsey gave the impression he could not care less…



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Rapid method of isolating tumor-targeting T cells could propel personalized cancer treatment


A cell infused with a special enzyme interacts with a tumor-targeting immune cell—a process that enables the immune cells to be easily captured and leveraged for a cancer treatment. Credit: Image courtesy of the Wu laboratory at Scripps Research

When it comes to defeating cancer, some immune cells are mightier than others. But even the best-trained eye and today’s advanced scientific tools have trouble discerning the most powerful tumor-fighting cells from the rest.

A new technique developed at Scripps Research by scientist Peng Wu, Ph.D., aims to change that—offering a new platform that could propel personalized cancer treatments that have been hindered due to the challenges of isolating the most useful immune in patients. The development is published October 22 in Cell.

“In many new and emerging personalized cancer therapies, the key to success is finding the sometimes-elusive T cells that are directly targeting the tumor, then creating more of those cells outside of patients’ bodies and re-introducing them for tumor treatment,” says Wu, associate professor in the Department of Molecular Medicine and senior author of the study. “With our simple method to detect and isolate tumor-reactive immune cells, my hope is that we can advance personalized immunotherapy treatments that are now either too costly or laborious to reach their potential.”

The method is called FucoID, named after the enzyme fucosyltransferase that plays a starring role in “tagging” the surface of sought-after immune cells so they can be seen and captured. The enzyme is loaded onto dendritic cells, a type of immune cell that presents tumor-specific material to the desired T cells. When the cells interact, the enzyme transfers a tag to the tumor-fighting cells so scientists can detect them with a fluorescent probe and extract them from the sample.

In experiments involving mice, the approach successfully identified multiple types of so-called “tumor antigen-specific T cells,” including CD4+ and CD8+ T cells that infiltrate tumors and attack from within. These cells are central to certain cancer immunotherapies—including checkpoint inhibitors and treatments known as adoptive TIL (tumor infiltrating lymphocyte) transfer therapies.

“This approach removes a significant barrier to studying tumor-specific T cells and will be immensely useful for both basic scientists and clinicians,” says John Teijaro, Ph.D., associate professor in the Department of Immunology and Microbiology and co-author of the study.

“This study also highlights how the highly collaborative environment at Scripps Research fosters innovative solutions to intractable problems.”

The FucoID process of isolating the appropriate cells takes only one day, compared with four or five weeks using current methods, according to Wu. “Once we isolate them, we can expand them into millions or billions of cells to construct a treatment or simply to study them,” he says.

Having the ability to quickly take stock of these cells in a patient can also help doctors predict therapeutic success or treatment progress, he says. And doing any of these things faster than today’s methods, which rely on bioinformatics or genetic manipulations, can make a big difference to patients.

Wu is now collaborating with clinicians at UC San Diego to use FucoID to isolate the desired T cells from human patient tumor samples, with the goal of eventually applying the platform to a clinical trial for a treatment.

“We believe FucoID has potential to be translated to a clinical setting for the detection and isolation of -reactive , ultimately paving the way for lowering the cost and accessibility of personalized ,” Wu says.


New connections reveal how cancer evades the immune system


More information:
Zilei Liu et al, Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation, Cell (2020). DOI: 10.1016/j.cell.2020.09.048

Citation:
Rapid method of isolating tumor-targeting T cells could propel personalized cancer treatment (2020, October 22)
retrieved 22 October 2020
from https://medicalxpress.com/news/2020-10-rapid-method-isolating-tumor-targeting-cells.html

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WHO doctor warns against lockdowns as primary method of pandemic control


A person wearing a face mask walks across London Bridge, with Tower Bridge in the background, at sunrise in London, Monday, Oct. 12, 2020. In response to the coronavirus’ resurgence, British Prime Minister Boris Johnson is expected to announce in Parliament on Monday a three-tier local lockdown system, formally known as “Local COVID Alert Levels,” for England, his office said. (AP Photo/Matt Dunham)

OAN Newsroom
UPDATED 10:46 AM PT – Monday, October 12, 2020

A World Health Organization doctor is urging world leaders to stop using lockdowns as their primary method to control the spread of COVID-19.

The organization’s special envoy on COVID-19, Dr. David Nabarro, expressed concerns over the widespread economic consequences of prolonged lockdowns. He said such measures can be justified to “buy time” and allow officials to “regroup” and “reorganize. “However, he also noted that “by and large, we’d rather not do it.”

“So we’re saying that we really do have to learn how to coexist with this virus in a way that doesn’t require constant closing down of economies, but at the same time is not associated with high levels of suffering and death,” he explained. “It’s what we are calling the middle path.”

Dr. Nabarro went on to warn extended lockdowns present a clear threat to society’s most vulnerable. He said, “lockdowns just have one consequence and that is making poor people an awful lot poorer.”

RELATED: Analyst — The 2020 race has become lockdowns vs. recovery





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Novel method presents possibilities for rapidly making and testing vaccine formulations — ScienceDaily


Northwestern University researchers are casting a net for nanoparticles.

The team has discovered a new, rapid method for fabricating nanoparticles from a simple, self-assembling polymer. The novel method presents new possibilities for diverse applications, including water purification, diagnostics and rapidly generating vaccine formulations, which typically require many different types of molecules to be either captured or delivered at the same time.

Using a polymer net that collapses into nanoscale hydrogels (or nanogels), the method efficiently captures over 95% of proteins, DNA or small molecule drugs — alone or in combinations. By comparison, loading efficiency is typically between 5% and 20% for other nanoparticle delivery systems.

“We use a polymer that forms a wide net throughout an aqueous solution,” said Northwestern’s Evan A. Scott, who led the study. “Then we induce the net to collapse. It collects anything within the solution, trapping therapeutics inside of nanogel delivery vehicles with very high efficiency.”

“It works like a fishing net, which first spreads out due to electrostatic repulsion and then shrinks upon hydration to trap ‘fish,'” added Fanfan Du, a postdoctoral fellow in Scott’s laboratory.

The paper was published last week (Sept. 29) in the journal Nature Communications.

Scott is the Kay Davis Professor of Biomedical Engineering at Northwestern’s McCormick School of Engineering. Northwestern professors Monica Olvera de la Cruz and Vinayak Dravid coauthored the paper.

Molecules found in nature, such as DNA and peptides, can rapidly self-assemble and organize into diverse structures. Mimicking this process using human-made polymer systems, however, has remained limited. Previously developed processes for self-assembling drug delivery systems are time consuming, labor intensive and difficult to scale. The processes also tend to be woefully inefficient, culminating in a small fraction of the drug actually making it inside the delivery system.

“Clinical application of self-assembled nanoparticles has been limited by difficulties with scalability and with loading large or multiple therapeutics, especially proteins,” Scott said. “We present a highly scalable mechanism that can stably load nearly any therapeutic molecule with high efficiency.”

Scott’s team found success by using a polypropylene sulfone (PPSU) homopolymer, which is highly soluble in dimethylsulfoxide (DMSO) solution, but forms electrostatic and hydrophilic aggregates in water. The aggregates are amphiphilic, which causes them to assemble into networks and eventually collapse into gels.

“Adding more water induces the network to collapse, leading to the formation of nanogels,” Du said. “The manner in which water is added affects the PPSU chain formation, which changes the nanogels’ size and structure.”

Atomistic simulations — performed by Baofu Qiao in the Olvera de la Cruz group — confirmed that the nanostructures were stabilized by weak sulfone-sulfone bonding. Using coarse-grained simulations performed by Northwestern postdoctoral fellow Trung Dac Nguyen, the researchers observed the nanonet structures. This opens a new avenue for soft materials assembly by means of sulfone-sulfone bonding.

In addition to drug delivery applications, the researchers also believe the novel method could be used for water purification. The network could collapse to collect contaminants in water, leaving pure water behind.

Story Source:

Materials provided by Northwestern University. Original written by Amanda Morris. Note: Content may be edited for style and length.



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Live imaging method brings structural information to mapping of brain function — ScienceDaily


To understand the massive capabilities and complexities of the brain, neuroscientists segment it into regions based on what they appear to do — like processing what we sense or how to move. What’s been lacking, however, is an ability to tie those functional maps precisely and consistently to matching distinctions of physical structure, especially in live animals while they are performing the functions of interest. In a new study, MIT researchers demonstrate a new way to do that, providing an unprecedented pairing of functional mapping in live mice with distinguishing structural information for each region all the way through the cortex into deeper tissue below.

“Our study shows for the first time that structural and functional coupling of visual areas in the mouse brain can be detected at sub-cellular resolution in vivo,” wrote the authors based in the lab of Mriganka Sur, Newton Professor of Neuroscience in The Picower Institute for Learning and Memory and the Department of Brain and Cognitive Sciences at MIT.

The technique could give scientists more precise ways to distinguish the borders and contents of regions they wish to study and could help them better understand the way that structural distinctions develop within individuals in different functional regions over time. Sur’s lab, for instance, is intensely interested in understanding the especially complex development of vision. Humans have 35 or so distinct functional regions that contribute to processing vision, Sur notes, and even mice have 10.

“There is something profound in the way that vision is represented and created in mammalian brains,” Sur said. “Where do these areas come from, what do they mean and what do they do? It has not been easy to understand how they differ. The critical thing is to precisely map or match the functional representation of each area with its anatomical uniqueness.”

Combining function and structure

To develop tools to help answer those questions, postdoc Murat Yildirim led the study published in Biomedical Optics Express. In it he describes how the research team combined a method of charting functional areas — retinotopic mapping — with deep structural information measured by a technology he has helped to pioneer — third-harmonic generation (THG) three-photon microscopy.

In retinotopic mapping, researchers can identify functional regions by engineering neurons to flash when they become electrically active (and show changes in calcium) in response to a particular stimulation. For example, scientists could show a mouse a pattern moving across a screen and mark where neurons light up, with each area showing a characteristic location and pattern of response.

Three-photon microscopy can finely resolve individual cells and their smaller substructures as deep as a millimeter or more — enough to see all the way through the cortex. THG, meanwhile, adds the capability to finely resolve both blood vessels and the fibers of a material called myelin that wrap the long, tendrilous axons of many neurons. THG does not require adding any labeling dyes or chemicals.

Crucially, THG yields an important optical measure called effective attenuation length (EAL), which is a measure of how much the light is absorbed or scattered as it moves through the tissue. In the study, Yildirim and co-authors show that EAL specifically depends on each region’s unique architecture of cells, blood vessels and myelin. They measured EAL in each of six visual functional regions and showed that the EAL significantly differed among neighboring visual areas, providing a structural signature of sorts for each functional area. Their measurements were so precise, in fact, that they could show how EAL varied within functional regions, being most unique toward the middle and blending closer to the values of neighboring regions out toward the borders.

In other words, by combining the retinotopic mapping with THG three-photon microscopy, Yildirim said, scientists can identify distinct regions by both their function and structure while continuing to work with animals in live experiments. This can produce more accurate and faster results than making observations during behavior and then dissecting tissue in hopes of relocating those same exact positions in preserved brain sections later.

“We would like to combine the strength of retinotopic mapping with three-photon imaging to get more structural information,” Yildirim said. “Otherwise there may be some discrepancies when you do the live imaging of brain activity but then take the tissue out, stain it and try to find the same region.”

Especially as three-photon microscopy gains wider adoption and imaging speeds improve — right now imaging a millimeter deep column of cortex takes about 15 minutes, the authors acknowledge — the team expects its new method could be used not only for studies of the visual system but also in regions all around the cortex. Moreover it may help characterize disease states as well as healthy brain structure and function.

“This advance should enable similar studies of structural and functional coupling in other sensory and non-sensory cortical areas in the brains of mice and other animal models,” they wrote. “We believe that the structural and functional correlation in visual areas that we describe for the first time points to crucial developmental mechanisms that set up these areas, thus our work would lead to a better fundamental understanding of brain development, and of disorders such as Alzheimer’s, stroke and aging.”

The National Institutes of Health, the National Science Foundation, The JPB Foundation and the Massachusetts Life Sciences Initiative provided funding for the study.



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The Scientific Method: How scientists solve problems


Michael Ryan, chief of WHO”s emergency response programme, said back in March that the organisation does not “generally recommend the wearing of masks in public by otherwise well individuals.”

Three months later, WHO has made a complete 180 on this stance. “WHO advises that governments should encourage the general public to wear masks where there is widespread transmission and physical distancing is difficult,” WHO chief Tedros Adhanom Ghebreyesus said in a June press conference.

Over the course of the COVID-19 pandemic, we’ve seen this happen numerous times with various issues, from the effectiveness of hydroxychloroquine to the debate on whether or not COVID-19 reinfection is possible.

If science was supposed to help us separate fact from fiction, why is scientific advice from experts constantly shifting when the world needs certainty the most?

Watch our explainer in the video player above where we raise the curtain on the scientific process, with the help of Nature’s Dr Magdalena Skipper and Cell’s Dr Deborah Sweet.



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US election 2020: Method Americans use to vote could become the story of the year | US News


Nothing about 2020 in America has been predictable.

An unexpected pandemic brought a mighty nation to its knees, the death of a black man sparked an international moment of racial reckoning, and a buoyant economy plunged into recession.

But there’s even more jeopardy to add to the mix now – and in Detroit, Michigan, you can really feel it.







US post ‘choked’ to ‘undermine confidence’

Plenty of people we spoke to aren’t certain the country will get a result on election night. And if things don’t go well for Donald Trump, they’re not sure he’ll accept it.

The fact is, the method Americans use to vote could become the story of 2020.

More people than ever before will be placing votes.

Yet the president has called the United States Postal Service (USPS) a “joke” – claiming without evidence, that universal mail in voting is riddled with fraud and can’t be trusted.

More from Us Election 2020

Meanwhile, Postmaster General Louis DeJoy has been making controversial cuts many blame for big delays in deliveries.

At a post office in Detroit, a crowd of Democratic leaders and union workers are enraged, casting Mr Trump’s criticism of USPS as an act of political sabotage.

Congressman Dan Kildee tells the crowd: “The president of the United States is choking off essential support to USPS in order to prevent people from casting their ballot. Shame on him.”

In this city workers have already had their overtime cut and are doing six-day weeks.

Vital deliveries like medication are being delayed.

One man tells me four sorting machines that can process more than 30,000 items every hour have been removed from just one station.

And yet there is a defiant faith in the agency.

Many gathered firmly believe the postal service will do what’s needed.

Congresswoman Brenda Lawrence, who used to work for the service, tells me: “USPS has a much longer tenure and trust with the American people than Donald Trump… the postal service is the only organisation that every single day touches every single household, six days a week.”

There are counties in Michigan and elsewhere though that are already working on a Plan B – setting up drop boxes for people to leave their ballots instead of posting them.

What isn’t clear is whether the president’s criticism of the agency will undermine public faith in the electoral process and stop them voting at all.

Roscoe Woods, president of America’s Postal Workers Union, told me: “By screwing with delivery standards and delaying mail, you undermine public confidence.”

:: Listen to Divided States on Apple podcasts, Google Podcasts, Spotify, and Spreaker

He says right now they have a 91% approval rating.

It is perhaps why Democrats were able to so effectively campaign against cuts.

The Post Master General has now suddenly said he’s delaying reforms until after the election to prevent it looking like they’re trying to interfere with it.

But there’s a long way to go – 78% of people will be eligible to vote by mail this year.

It’s going to put the system under unprecedented pressure.



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FDA approves Yale saliva COVID-19 testing method


FILE – In this July 23, 2020 file photo, health care workers prepare a COVID-19 test sample before a person self-administered a test at the COVID-19 drive-thru testing center at Miami-Dade County Auditorium in Miami. (David Santiago/Miami Herald via AP)

OAN Newsroom
UPDATED 7:09 AM PT – Monday, August 17, 2020

Yale University researchers may have changed the coronavirus testing game with a new method solely based on a person’s saliva.

The FDA recently issued emergency authorization for Yale’s SalivaDirect method, which was developed in their School of Public Health. The new method attempts to provide a less expensive, less invasive and simpler way to test.

“The results that we were seeing seeing for the saliva examples were even in some cases better than what we we’re seeing in nasopharyngeal. These were COVID-confirmed patients that we were initially testing, so they should have been testing positive for SARS-CoV-2.” 

— Anne Wyllie, PhD, Associate Research Associate of Epidemiology – Yale School of Medicine

SalivaDirect testing became popular with its effectiveness in diagnosing asymptomatic NBA staffers and players. Researchers found the testing produced similar results to nasal swab tests, but came in less than three-hours.

They also found saliva samples can remain stable in prolonged periods of time in warmer areas. On top of that, the samples are flexible enough to produce similar results with different chemical compounds.

“And overall it’s faster, so it can really be scaled up so more tests can be done and that is really gonna help to, you know, ramp up testing,” explained Dr. Chantal Vogels, Postdoctoral Fellow at the Yale School of Public Health. “It’s gonna be more scalable, it’s gonna be more accessible and we’re just really exited about that.”

Researchers don’t intend on commercializing their tests, which are estimated to cost around $10 per test. They hope their new method can be used to help struggling communities worldwide.

RELATED: Modi says India set to mass produce COVID-19 vaccine, launches digital health mission





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The Fat Loss Extreme Method



So you want to shred fat and you want to do it quickly?

Join the club. If there was an “I want to be thinner” club, probably everyone on the planet would be part of it. However, you’re different. You’re determined and you’re willing to put in the work. That already makes you better than most others out there.

But how do you make sure you’re actually able to reach your fat loss goals?

Well, you’ll need to follow a strict workout and diet regimen. For fat loss extreme you’ll need to be even more dedicated. You’ll also need to be careful, as it is easy to go so extreme that you end up causing problems for your body instead of finding solutions. But not to worry.

We have the answers to all your fat loss extreme questions right here. No matter your body type or where you are with your physical fitness, you can begin to shred the weight and see a new and improved you.

Want To Learn More About Fat Loss Extreme? Read Below!

What Is Weight Loss?

what is weight loss

Of course, you know what weight loss is. It’s when your body sheds fat and you can see the muscle underneath.

But what causes weight loss?

Weight loss is only caused by burning more calories than you bring in. It’s all about calories.

Yes, there are carbs and proteins and fats and all that stuff, but the only way to achieve weight loss is to burn more calories than you bring in. 2,000 calories a day is 2,000 calories a day is 2,000 calories a day. It doesn’t matter if you bring it in from protein, carbs, or fats.

Now, your body will react differently to these different sources of energy, so it may appear as if your body sheds more weight when eating one food type over the other, but the primary reason behind this is the amount of water your body retains based on what you eat. But we’re not talking about water retention weight. We’re talking about fat loss.

So, in order to burn weight and achieve extreme fat loss, you will need to burn far more calories in a given day than what you take in (Healthline, 2018).

Can’t You Just Fast For A Few Days?

fasting

So, if burning fat means you are in a caloric negative wouldn’t that mean you could just fast for a few days (or as long as possible) in order to burn off those calories? Well, not exactly.

Intermittent fasting has grown in popularity in recent years, although that is more skipping a meal (or two) from time to time. Prolonged fasting can have a negative effect on your body and it may actually cause the exact opposite result you’re looking for.

You see, when your body goes for an extended period of time without taking in calories it moves into survival mode. At this time your body will slow down its metabolism and, at the same time, it will shift from burning fat cells for energy to burning muscle cells for energy.

After a prolonged state of fasting, you may continue to lose weight, but you won’t be losing fat. You’ll be losing muscle, and this is the last thing you want to do. Larger muscles burn more calories, which means if your muscles shrink you’ll burn fewer calories during the week.

All of this is a problem and will end in undesired results. So, while extreme fat loss is a goal, you will need to continue to eat and bring in calories, otherwise, your body will begin acting in ways that are not healthy to your overall wellbeing (WebMD).

What Is Extreme?

extreme

Now, before we dive into the workout we need to cover what “extreme” actually means. If you have it in your head that you’re going to drop 30 pounds by the end of the month we probably have bad news for you.

Switching your diet in the first week might help you drop five or even 10 pounds, although most of this will be shedding water. In terms of shedding actual fat, it does take a little longer in order to do it safely.

Celebrities and Weight Loss

You’ve probably heard of celebrities and their crazy crash diets. Crash diets are dangerous. These kinds of diets may result in temporary weight loss, but these are not sustainable at all. After a week or two, you will likely need to quit the diet, and when you do that you might end up binging on the food you avoided.

Celebrities are able to do this due to all the nutritionists and specialists at their disposal, and even then, it isn’t usually safe. If you try a crazy crash diet and fitness routine there’s a good chance you might end up feeling light-headed throughout the day, have trouble focusing on your daily activities, and put yourself in danger while doing everything from lifting to driving your car.

Instead, you need a safe “extreme” fat loss routine. It doesn’t mean you won’t see weight loss results, but what it does mean is you’ll go about doing it safely.

Safe “extreme” weight loss will help ensure you maintain the weight loss as well. There isn’t much of a point of you doing a crash diet only to put on more weight shortly after.

The Workout Routine

the workout routine

When you’re coming up with a fitness goal you need to decide whether you want to put on muscle or shed fat.

There are some routines that will help with both, but because you’re not specifically focusing on one or the other you can’t completely dedicate your routine to weight loss or to muscle gain.

This is important to consider because your fitness routine will differ based on what it is you want to do. If you’re still reading this far down into the article it means you absolutely are serious about fat loss. The following workout routine is designed to maximize your fat loss and to help you scorch those fat cells.

With a muscle-gain specific workout, you would break your workouts up a bit.

You would likely focus on a muscle group or a muscle movement and hit those groups of muscles hard each day. That, however, is not what you’ll be doing with a fat loss extreme workout. Instead, you want to try and work for every muscle group during your workout.

Now, with this workout, you’re not going to completely deplete your energy in each muscle group to the point of not being able to squeeze out one more rep. This kind of workout will shred your muscle fibers, which in turn will require you to give those muscle fibers a day or two breaks before hitting them again. Otherwise, you’re not giving your muscles enough time to recover.

With a fat loss extreme workout, you are working your muscles, ensuring your muscles get a nice burn and sustain some damage, but because you’re not pushing these muscles to the extreme every day the fibers will be able to recover within the 24-hour window and be ready for your next workout.

This gives you maximum calorie burn throughout the day to help you achieve your desired results.

With your workout, you’ll want to make sure you hit every muscle group. Again, you don’t want to overtax the muscles, just make sure each is hit. For each exercise, we recommend performing three to four sets and shooting for eight to 12 reps each. Stop at 12.

If you know you can squeeze out more reps than 12 just add weight to the next set. You want to challenge yourself and burn calories, so don’t just go super light. Make it a doable challenge.

On the first day, you should start with a bench press. From there, switch to a squat. Now go to a pull-up, followed by a lunge (12 reps on each side). Follow this up with a chin-up, then a dumbbell row and deadlift. These will work for just about every muscle group in your body. You also don’t have to switch between your upper body and lower body, but doing so will help give any crossover muscles a few minutes to recover before being used again.

Every workout day should try to hit every muscle group. Thankfully, because you’re only performing one or at most two lifts per muscle group, it is easy enough to switch everything up and to keep your workouts interesting. You can also swap between dumbbells, barbells, body weight, and resistance bands.

Keeping your body guessing as to how you’re going to live will help maximize the number of calories you burn (once your body becomes accustomed to your lifting method it will cut down on the calories it burns because it will be more efficient in how it handles your exercises).

So, for example, your second-day workout routine can include a sumo squat, a chest press, rear lunges, dumbbell shrugs, tricep extensions, and a lat pull down.

If you feel like one area of your body isn’t being utilized enough during one of the given days you can add in a second exercise. But again, don’t overdo it.

Because you’re going to be using all your muscles every day you can’t completely obliterate one particular muscle group. This means if you’re really trying to grow your arms don’t work your biceps hard every day. This prevents your muscles from being able to recover and rebuild the torn muscle fibers.

As an added bonus you will want to perform some kind of ab workout every day. Of course, you can hit your abs every day (and hit them hard every day).

Your core muscles are accustomed to being put under great stress as these stabilizing muscles are used to hold your body up, so they are often engaged. It’s also why it is so much more difficult to build large ab muscles as these muscle fibers are naturally tight due to constant use.

So, if you want to grow your abs as well as shed weight you’ll want to perform an ab workout every day (five to 10 minutes max should be more than enough. You can perform 45-second sets of different ab exercises for this).

In Conclusion

Fast weight loss can be achieved if you’re truly dedicated to it. You’ll need to focus both on your diet and your workout routine in order to burn more calories and to cut down on the calories you bring in.

So, if you’re able to dedicate yourself to this kind of routine you absolutely will be able to see results in a short period of time. This might not be a diet and workout routine you’re able to maintain for months on end, but it is a good option to integrate it throughout the year.

This way you’ll get a natural boost in your weight loss whenever you decide to add it to your workout and diet regimen. And, of course, if you have more questions about weight loss, exercise, or anything else fitness related, make sure to keep it right here. We have plenty of goodies to satisfy your needs.

-Terry Asher

Terry Asher

After changing his best friend’s life by helping him lose over 70lbs, dropping him down to an amazing 7% body fat, Terry was inspired to be a full-time internet trainer knowing he could do the same for many more. In 2010, Terry published his own diet and fitness e-book that can be purchased on this website. Let Terry help you change your body for the better!

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Summary

Article Name

The Fat Loss Extreme Method

Description

For fat loss extreme you’ll need to be even more dedicated. We have the answers to all your fat loss extreme questions right here. No matter your body type

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Terry Asher

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New COVID-19 testing method ‘droplet biosensing’ gives results in minutes


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