Delivering drug straight to the brain could cut required dose by as much as 75 per cent — ScienceDaily


A team of neuroscientists and engineers at McMaster University has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body.

The leap in efficiency means patients with schizophrenia, bipolar disorder and other conditions could see their doses of powerful antipsychotic medications cut by as much as three quarters, which is expected to spare them from sometimes-debilitating side effects while also significantly reducing the frequency of required treatment.

The new method delivers medication in a spray that reaches the brain directly through the nose, offering patients greater ease of use and the promise of improved quality of life, including more reliable, effective treatment.

Ram Mishra, a Professor in the Department of Psychiatry and Behavioural Neurosciences and Co-Director of McMaster’s School of Biomedical Engineering, and Todd Hoare, a Canada Research Chair and Professor of Chemical Engineering, describe their research in a newly published article in the Journal of Controlled Release.

They and their co-authors Michael Majcher, Ali Babar, Andrew Lofts, and Fahed Abuhijleh have proven the concept of their new delivery mechanism in rats, using PAOPA, a drug commonly prescribed to treat schizophrenia.

A problem for patients using antipsychotic medications, Mishra explains, is that taking them orally or by injection means the drugs must pass through the body before they reach the brain through the blood. To be sure enough oral or injected medication reaches the brain, a patient must take much more than the brain will ultimately receive, leading to sometimes serious adverse side effects, including weight gain, diabetes, drug-induced movement disorders and organ damage over the long term.

When delivered through the nose, the spray medication can enter the brain directly via the olfactory nerve.

“The trick here is to administer the drug through the back door to the brain, since the front door is sealed so tightly,” Mishra says. “This way we can bypass the blood-brain barrier. By delivering the drug directly to the target, we can avoid side effects below the brain.”

Mishra and collaborator Rodney Johnson of the University of Minnesota had previously created a water-soluble form of the medication, which was used in the current research. The new form they created was easier to manipulate, but they still lacked an effective vehicle for getting it to the brain. A particular issue was that drugs delivered via the nose are typically cleared from the body quickly, requiring frequent re-administration.

Hoare, in the meantime, had been working with an industrial partner to develop the use microscopic nanoparticles of corn starch for agricultural applications.

The two scientists, who work across campus from one another, came together after researchers in their labs met at an internal McMaster conference. Two of the researchers, Babar and Lofts, worked on the project in both labs.

The engineering team was able to bind the drug to the corn starch nanoparticles that, when sprayed together with a natural polymer derived from crabs, could penetrate deep into the nasal cavity and form a thin gel in the mucus lining, slowly releasing a controlled dose of the drug, which remains effective for treating schizophrenia symptoms over three days.

“The cornstarch nanoparticles we were using for an industrial application were the perfect vehicle,” Hoare says. “They are naturally derived, they break down over time into simple sugars, and we need to do very little chemistry on them to make this technology work, so they are great candidates for biological uses like this.”

The gradual release means patients would only need to take their medication every few days instead of every day or, in some cases, every few hours.

The research work was funded by a Collaborative Health Research Partnership Grant (from the Natural Sciences and Engineering Research Council of Canada and the Canadian Institutes of Health Research) and McMaster University’s Interdisciplinary Research Fund.

The researchers are seeking a corporate partner to move the technology into the marketplace.

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Supplement Company of the Month: Olympus Lyfestyle


Admittedly, Olympus Lyfestyle doesn’t fit perfectly with the moniker “Supplement Company of the Month.” It was a supplement company in its prior incarnation, Olympus Labs, but Olympus Lyfestyle is, as the name suggests, a lifestyle brand. But don’t worry, that lifestyle incorporates taking supplements that Olympus creates and sells to consumers like you, including here on Bodybuilding.com.

The distinction is more than mere semantics. It strikes at the heart of the personal journey of Olympus Lyfestyle founder and CEO Mobi Khawaja, a self-described millennial who is fully immersed in the way of lifting and living that he champions through his company. His philosophy revolves around—in no particular order—looking better, feeling better, and living better, all with a distinctive style and a highly elevated sense of purpose.

An Olympus Lyfestyle icon such as model Tyrone Hermitt works his ass off in the gym and has the body to show for it—that’s a given. But when you check his Instagram page, rather than seeing him crank out reps on the bench press, you’re more likely to see him embodying that famous line of Kanye West’s: “My life is dope, and I do dope shit.”

Bodybuilding.com will be showcasing Olympus Lyfestyle content in the coming months. In the meantime, we had the chance to ask Khawaja about his personal journey, what his brand stands for, and where it’s going from here.

Before you tell us about Olympus Lyfestyle, what’s your background?

I hold bachelor’s degrees in history, Asian studies, and criminal justice, as well as an executive MBA. Growing up, I was someone who took their hobbies and passions and did something about them. When I was 10 years old, I grew obsessed with anime, particularly Dragon Ball Z. So, I created a GeoCities website and taught myself HTML.

At the time, my friends would tease me and say, “HTML: How The Mobi Lives,” which I still remember to this day. But from GeoCities, I created my own branded website. I went on to co-webmaster a bigger website with a friend I had met through the community and AOL instant messenger. A few years later, I began an anime-based forum that amassed more than 50,000 members.

Then came the Xbox and the rise of Halo 2. At one point I was ranked top 100 in the world and always at the upper echelon of matchmaking. [Matchmaking is the process of connecting players together for online play sessions, usually by skill level]. This was something I greatly enjoyed, as it brought my closest friends together and connected me to the world. I wasn’t a casual gamer; I was extremely competitive. I ranked high in every game I played. I probably could have had an alternate life as a pro gamer.

But I was very skinny, which eventually drove me into the gym. It took a while, but over time, I began to really enjoy learning the science behind exercise. At age 16, I began using supplements. I devoured everything I could find on supplements, and quickly saw areas where companies and their products fell short. So, I started to look into clinical doses of various ingredients, and I began self-dosing. I’ve always been one to take things into my own control. There’s so much knowledge out there, and if you’re hungry and driven, you can learn so much on your own.

When did you decide to start Olympus Lyfestyle, and why?

Olympus Lyfestyle is the second brand that I’ve started. The first brand, Olympus Labs, was too product-focused and disconnected from what fueled me personally. I’ve always been a super-user, turning my hobbies and passions into business ventures. So, I wanted to start a lifestyle brand built on connecting with an audience, engaging with them, and creating a relationship that transcends mere transactions. I was inspired by disruptive companies “making it and breaking it” in the digital realm.

Did you feel like you were filling a void in the market, or simply bettering what others were doing?

With our first company [Olympus Labs], we were definitely doing things better than other companies by structurally having the advantages in supply chain, R&D, etc. But in hindsight, the brand was too product-centric and -focused. We now live in an era where branding needs to be about the user and delivered to the user. Being a millennial myself, it was easy for me to adopt that mindset.

With this new brand, not only are we creating products that have what we think are the best formulations and best flavors, but we’re also creating a brand that is experientially enriching for our consumers through our content-deployment strategy. Our strategy involves radical engagement, creating content that causes consumers to engage and connect with the brand on a brand-customer level, and then introducing those consumers to the product and its benefits for their lifestyle. To look better, feel better, and live better—those are the benefits.

Let’s turn to your customers. Is there a typical Olympus Lyfestyle customer?

Our target audience is a socially and culturally connected healthy lifestyle audience. They are someone who is highly engaged with the brand they follow. Someone who looks to find meaning in the brand associations they have and carry. They are young, hip, disruptive individuals looking to live a healthy lifestyle with the support of a brand that syndicates pop culture, fashion, fitness, and sports performance in their brand messaging and merchandising strategy.

Olympus Lyfestyle

Living a healthy lifestyle is a means to fuel their “Why.” They want to feel good and look good, tying in both the aesthetics of beauty and fitness. Bottom line, they want to live better.

What product do you feel helped you the most in getting known in the supplement industry?

Rather than one product, it’s been the consistency of each of our product formulations, and the addition of new and novel ingredients. I also think we’ve changed the pace at which the industry moves. There is a reason why we’ve won many supplement awards.

Having said that, I think the product that will amplify growth for us is our Promises Protein Powder. Not only does it contain real cereal pieces, but in my opinion, it’s simply the best-tasting protein on the market right now.

What was the inspiration for your brand’s packaging? That’s an interesting aesthetic.

Our brand messaging in content is very mature, fashionable, and cool. Our packaging strategy is more fun, animated, and illustrated to display around the flavor and fun of the products. In the future, we’ll be bringing it up another notch by using iridescent bottles.

Before I let you go, in one sentence, sum up your brand message.

We’re devoted to bringing fitness to your lifestyle and creating a “Lyfestyle” you can follow!



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Skinimalism: 2021’s Biggest Beauty Trend


The new wave of natural, minimal or no-makeup beauty looks where your real skin — texture, pores, blemishes, discoloration, and all — shines through is what Skinimalism is all about.

Followed by many last year and popularised by one & all, skinimalism is all about simplifying your skincare routine. It promotes embracing the skin’s natural texture and finding products that help it glow naturally. It’s about following a minimalistic skincare routine and taking it easy on the skin.

What Skinimalism Consists Of?

The three steps to a simplified skin routine.

Facial Yoga

Experts have seen a spike in the search for face yoga. It’s considered to be a fresh and effective approach towards skincare. It helps you attain a natural glow and release facial tension. Face yoga comprises of a series of toning and strengthening exercises for the muscles of your face.

facial_yoga

Exercises include rolling the tongue to make vibrating sounds and exaggerated yawns to release the jaw muscles. It also involves laughing a lot out loud and blowing kisses. Relaxing your face is an important part of yoga because the face is an indicator of tension in the rest of the body.

Asanas for keeping one’s skin healthy and rejuvenating are Kapalbhatti, Pranayam, Sarvangasan, Shirsasan, Dhanurasan and Salabhasan.

Minimum and Natural Makeup

Using a minimum number of products to get clear, flawless skin and a natural flush of colour is the essence of skinimalsim. It’s more about using skin-friendly products with lightweight formulas that give sheer coverage that’s comfortable to the skin.

Makeup Artist Bobbi Brown shares an insight of her daily skin care & make-up routine in her interview with Women Fitness “I’m 63-years-old and I keep my daily skin care routine very simple. First, I’m not wearing a lot of makeup these days so that really helps. At night, I wash my face with either coconut oil or a natural cleanser.” She believes that following a regular wellness routine of drinking lots of water, eating well and incorporating good fats into your diet throughout the day makes a huge difference in the health of your skin. Which is so very true.

Homemade Skincare

skinimalism

This trend will not go anywhere even in 2021. While 2020 positioned skincare products as essentials, home remedies became the essence of skincare. Look for natural ingredients that suit your skin, and choose at-home skincare over harsh products.

Model Miranda Kerr‘s secret skin care weapon is, Rosehip oil, full of antioxidants and fatty acids and the fresh-faced angel credits her lack of stretch marks to frequent application throughout her pregnancy.

For more on, Creating an at Home Spa Ritual, click here.

Disclaimer
The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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Top Waterwomen Charge Big-Wave Season in Hawaii


Until you’ve seen big-wave surfing up close, it’s hard to understand just how massive and intimidating these waves really are. Towering walls of water loom on the horizon, getting larger and larger until they finally break in a thundering explosion of whitewater. It’s one of those things that if you’ve seen it and felt it, most people quickly realize they don’t want to be apart of it.

Any human that decides to paddle themselves past the point of no return and leap to their feet is doing an incredible job of fear management. The reward for successfully riding one of these waves is an unrivaled adrenaline rush, the risk is a vicious wipeout that can easily cause serious injury or even death.

While top big-wave surfers like Kai Lenny, Grant Baker and Billy Kemper get a lot of the spotlight for their big-wave riding abilities, there’s another group of chargers that are finally beginning to get the attention they deserve.

Top waterwomen are getting a big platform this season to showcase their big-wave riding prowess thanks to Red Bull Magnitude. This big-wave video contest kicked off last month and will crown the waterwoman that performs the best throughout the entire Hawaiian winter big-wave season. Here’s a look back at the heaviest moments that went down in December, and with the giant swell coming in this weekend, this competition is far from over.


For access to exclusive gear videos, celebrity interviews, and more, subscribe on YouTube!



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PERSONALITY PROFILING | Psychology of Adolf Hitler | Which personality type was Adolf Hitler?



Watch this video to find out: https://youtu.be/LFetrs6_jPg

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Is remote working making imposter syndrome worse?


Do you often find yourself faced with feelings of not being ‘good enough’, or that you’ve tricked others into thinking you’re better than you are? A new study has found that you’re not alone

Imposter syndrome is on the rise, according to a study by work management tool Asana. The global study, which sampled 13,000 people – including 2,010 from the UK – has found that the levels of those experiencing imposter syndrome have hit 69%, with 45% saying this has worsened for them since working in a remote environment.


What is imposter syndrome?

Do you ever find yourself second-guessing your qualifications? Feel as though you’ve tricked those around you into accepting you? Believe everything that has happened to you is just luck? Or experience a persisting feeling of being inadequate? This is imposter syndrome.

Rooted in self-doubt, imposter syndrome tells us that we’re not good enough, or that we shouldn’t have the things that we have. It’s rooted in anxiety, linked to perfectionism, and can lead to other mental health problems such as burnout and depression.


Assessing the findings, researchers from Asana have linked this increase to our switch to remote working during lockdown – with less support and communication between colleagues leaving space for anxious thoughts to manifest themselves unchecked.

Speaking to this, Asana’s head of EMEA, Simon O’Kane said: “Our latest research illustrates the increased levels of imposter syndrome, anxiety and burnout many British office workers are currently experiencing.

“With a third lockdown in place, and many now facing the prospect of more remote working in the weeks and months ahead, never has it been more important for companies to not only look after the wellbeing of their staff, but also fully understand the unique challenges their employees may be facing.”

Despite this advice, the study also found that just 19% of respondents felt confident enough to reach out to their employer to speak about the challenges that they are facing.



Speaking to Happiful about tackling imposter syndrome in the workplace, career coach and author Tessa Armstrong notes that imposter syndrome can lead us into vicious cycles of over-preparing and over-thinking tasks, which triggers self-doubt and anxiety. And it’s clear to see how that would be an easy trap to fall into while working remotely.

But there is a way out, and Tessa shares some great tips for addressing your own thinking, and catching yourself before you spiral into self-doubt.

Although it’s never easy, the first step to address any mental health problem is so often reaching out to others. Talking about mental health at work might feel strange, or stressful, but the payoff for your wellbeing could be huge.


To find a life coach near you, head to lifecoach-directory.org.uk



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Health authorities say most of the travellers quarantining in South Australia will be released.



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Posted

January 15, 2021 17:07:03

South Australia will allow anyone from greater Brisbane into the state without having to quarantine from Sunday morning.


Source: ABC News
|
Duration: 38sec

Topics:

rural,

health-policy,

health-administration,

states-and-territories,

government-and-politics,

forms-of-government,

sa,

australia

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Public health officials provide new projections on COVID-19 cases, deaths


Federal public health officials will provide new modelling figures today on the number of projected COVID-19 infections and deaths in Canada.

The briefing will begin at 9:30 a.m. ET and CBCNews.ca will carry it live.

It comes as the number of cases continues to climb across the country, threatening to overwhelm more health systems and critical care units.

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NIMH » Showing Support for Basic Researchers


In my professional life, I have held many different roles. I am a psychiatrist who cares deeply for my patients, who spend much of their lives struggling with the burden of mental illnesses. I am a neuroscientist, deeply interested in the inner workings of the brain. More recently, as Director of NIMH, I am also an administrator, helping shape the direction of mental health research, from the most basic science to mental health services and intervention research.

In holding these multiple roles, I’ve gained a unique perspective on the field of mental health as a whole—the one thing I’ve observed, time and again, is that basic science is the foundation upon which everything else is built. Every day, thanks to the hard work and dedication of thousands of neuroscientists, we learn more and more about function and dysfunction in the brain, leading to better treatments for mental illnesses.

Given the foundational role basic science plays in the bench-to-bedside pipeline, accomplishments in basic science should be celebrated. However, because basic science frequently involves animal models, researchers investigating basic science often come under attack by animal rights activists. Dr. Elisabeth Murray, my colleague at NIMH, is one such researcher whose work has recently been targeted for her use of non-human primates.

Few neuroscientists have done more to enhance our understanding of the prefrontal cortex and its role in the control of fear, value-based decisions, and action planning than Dr. Murray. Over the better part of the past four decades, Dr. Murray has conducted a remarkable series of experiments that has clarified the brain mechanisms underlying complex behaviors that go awry in mental illnesses. In particular, her lab has pioneered the methods necessary to study these behaviors in Macaca mulatta, a species of non-human primate with a prefrontal cortex that closely resembles that of humans, a key factor enabling a deeper understanding of human brain diseases. Dr. Murray’s work has been incredibly important in laying the foundation for efforts to translate neurobiological findings into solutions that will improve the lives of those who live with mental illnesses.

Members of special interest groups have recently engaged in an unrelenting campaign against Dr. Murray, posting misleading videos and alarming social media messages about her work on the web; holding protests in her neighborhood in the midst of the COVID pandemic; and harassing her and other NIMH scientists with a disruptive series of phone calls, emails, and other intrusive requests whose main purpose is to interfere with their ability to carry out their crucial research.

One might wonder: Why are mental health researchers, such as Dr. Murray, being targeted? To me, it is all too plain. These groups take advantage of the unwarranted stigma that is still associated with mental illnesses today. The reality is that mental illnesses are like any other medical conditions—they are disorders of biological systems that demand a thorough and complete research response, including supporting basic science research. My patients suffer every bit as much as those with other illnesses and they are deserving of every bit of knowledge that Dr. Murray and her colleagues can generate.

To transform our understanding and treatment of mental illnesses, we must continue to deepen our understanding of the brain and how it functions. Animal studies are critical to advancing this brain science and NIMH will continue to support the hard-working scientists, such as Dr. Murray, who are using model organisms to gain insight into the body’s most complex organ.

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Things You Can Do Every Day to Keep a Healthy Spine


Things You Can Do Every Day to Keep a Healthy Spine

Things You Can Do Every Day to Keep a Healthy Spine : With all the hustle and bustle of daily activity, concerns for our bodily health, including the health of our spine, gets left behind, somewhere at the back of our minds and our heads. Often enough, the consequences of this chronic neglect will start to manifest in our middle age, through various back problems accompanied by excruciating pain.

All this has some element of the tragic to it — in the classical sense of the word – because of whether or not we’re going to develop spine conditions is somewhat dictated by our genes; but the modern misappropriation of the word still applies, since it’s not hard at all to take the necessary precautions to keep this from happening.

Keeping a straight back at work

Maintaining proper body posture while seated goes a long way towards keeping your spine in good shape. This is especially true today, when most women tend to work at a desk with a computer screen and keyboard in front of them.

Slouching for eight or more hours a day doesn’t just leave us with a sour back when standing up afterwards, but can have some serious repercussions in the long run. Everyone seems to agree that keeping a straight back is crucial for proper sitting, even if it might not come naturally at first.

We can achieve this very comfortably by propping our buttocks against the chair’s backrest, so that our lower spine comes in full contact with the back of the chair. Our feet should be flat against the ground, with ankles at 90 degrees. Our hands will naturally rest on the desk, and ideally, these should be in line with the surface.

So, the stereotypical schoolmarm telling her young pupils to “sit straight” is basically correct, apparently. She might be right with this one, but she’s wrong in other respects.

Do be restless in your chair!

Maintaining proper body posture might be a good general directive, but this doesn’t mean we should always sit at attention like we’re some Prussian military cadre. Keeping the same posture for long – even the proper one – can hurt our backs just the same.

If we have to stay seated for a long time, we should also remind ourselves to change position once in a while. This might seem like a no-brainer, but many of us tend to get so glued to what we are doing that we end up freezing in place for hours on end. Our bodies do cry out in pain when finally standing up afterwards, but the thought of changing our seated position never seems to come to fore.

Well, that pain might add over time to a serious health issue. Futzing around in your chair does a lot to prevent that, so moving your torso about while having to stay on your sit is always a good idea.

Exercise after idleness

While it might always be a good idea when at work to rise up from your chair, get in front of your manager, and with a decisive voice tell him “Hey, how’s it going!”, this will hardly be a sufficient workout as the daily requirements of your spine are concerned.

A number of studies, some of which drawing upon data collected from cohorts ranging in the tens of thousands of call center employees, concluded that people who exercise after work are a lot healthier that those who don’t. The causal relation can go either way; but following basic common sense, we might be better off hitting the squash course after a long day of sitting at work than doing some more sitting in front of a TV after a long day of sitting at work.

On sleeping

There are about three sleeping positions we can think of: on our backs, on our bellies, and on our sides. The back sleeping position is all well and good for the spine, but few of us actually practice it. Meanwhile, sleeping 180 degrees turned over, while it may feel comfortable at the time, can leave us with some serious middle-back soars in the morning.

That’s because our spines don’t align to the natural “S” positions while we’re belly-down with our heads on a pillow and our bodies following the down curvature of a soft mattress. If you just have to keep that posture to stay dormant, simply do away with the pillow and go for a stiffer mattress.

The side sleeping position agrees with our spines the most. This should seem obvious, as it gives us more freedom to arch our backs, and we can place some hands between our torso and the bed to control for the X-axis when needed. The only obvious drawback of side-sleeping is maintaining head support.

We generally do that with our upper arms, but after falling asleep, that position often changes into a spine-straining belly down. The best way to keep minimize the stress on our upper vertebrae when sleeping on our sides is to invest in a pillow that is at least as thick as either one of our shoulders is broad.

Correct lifting techniques

Judging by the high numbers of athletes that require spinal surgery, it is little surprise that physical strain can seriously damage our backs. In day to day life, this generally means lifting heavy objects.

In a nutshell the key to lifting well is to engage your hips, very much like when doing a squat. The back should be straight, with your chest kept forward and your arms engaged.

 

Author :

Brittany Elmore is the marketing department manager at Marina del Rey Hospital, a center specialized in spine services, rehabilitation, surgery and recovery.

 

 

 

 

 

Related Videos about Things You Can Do Every Day to Keep a Healthy Spine :

Spine Health Through Exercise

 

How to Keep Your Spinal Discs Healthy

 

Health & Fitness || How to Strengthen Spine?

 

Optimal Sitting Position for Spine Health

 

10 Easy Ways to Improve Your Back In No Time

 

Things You Can Do Every Day to Keep a Healthy Spine

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